α-Conotoxin PIA

CAS No. 669050-68-4

α-Conotoxin PIA ( )

Catalog No. M30729 CAS No. 669050-68-4

Selective antagonist of α6-containing nicotinic receptors that discriminates between the closely related α6 and α3 subunits (IC50 values are 0.95 and 74.2 nM for rat α6/α3β2β3 and α3β2 receptors respectively).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    α-Conotoxin PIA
  • Note
    Research use only, not for human use.
  • Brief Description
    Selective antagonist of α6-containing nicotinic receptors that discriminates between the closely related α6 and α3 subunits (IC50 values are 0.95 and 74.2 nM for rat α6/α3β2β3 and α3β2 receptors respectively).
  • Description
    Selective antagonist of α6-containing nicotinic receptors that discriminates between the closely related α6 and α3 subunits (IC50 values are 0.95 and 74.2 nM for rat α6/α3β2β3 and α3β2 receptors respectively).
  • Synonyms
  • Pathway
    Endocrinology/Hormones
  • Target
    AChR
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    669050-68-4
  • Formula Weight
    1981.3
  • Molecular Formula
    C79H125N27O25S4
  • Purity
    >98% (HPLC)
  • Solubility
    water:2 mg/mL
  • SMILES
    [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)C(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@@H](NC(=O)C(NC2=O)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(N)=O)NC1=O)C(C)C
  • Chemical Name

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dowell et al (2003) α-Conotoxin PIA is selective for α6 subunit-containing nicotinic acetylcholine receptors. J.Neurosci. 23 8445 PMID:
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